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Physiol. Genomics 16: 161-165, 2004; doi:10.1152/physiolgenomics.00204.2003
1094-8341/04 $5.00
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Received 5 December 2003; accepted in final form 8 December 2003.
Physiological Genomics 16:161-165 (2004)
1094-8341/04 $5.00 © 2004 American Physiological Society

Invited Review

Nutritional genomics

Patrick J. Stover

Cornell University, Division of Nutritional Sciences, 315 Savage Hall, Ithaca, New York 14853

The integration of genomics into nutritional sciences has illuminated the complexity of genome responses to nutritional exposures while offering opportunities to increase the effectiveness of nutritional interventions, both clinical and population based. Nutrients elicit multiple physiological responses that affect genome stability, imprinting, expression, and viability. These effects confer both health benefits and risks, some of which may not become apparent until later in life. Nutritional genomics challenges us to understand the reciprocal and complex interactions among the human genome and dietary components in normal physiology and pathophysiology. Understanding these interactions will refine current definitions of benefit and risk and lead to the establishment of dietary recommendations that have a high predictive value, minimize the risk of unintended consequences, and account for the modifying effects of human genetic variation. Furthermore, nutritional genomics will enable the design of effective dietary regimens for the prevention and management of complex chronic disease. This review focuses on new perspectives that have been presented to the nutritional sciences by the advent of genomics, and new challenges that demand attention because of their potential impact on, and immediate translation into, current public health nutrition recommendations and interventions.

nutrition; genetic variation; recommended daily allowance; single-nucleotide polymorphism; haplotype; mutation; selection






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