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Perspectives

Realizing the potential of zebrafish as a model for human disease

Division of Hematology/Oncology, Children's Hospital, Department of Medicine; and Howard Hughes Medical Institute, Children's Hospital, Boston, Massachusetts 02115

ABSTRACT

Barut, Bruce A., and Leonard I. Zon. Realizing the potential of zebrafish as a model for human disease. Physiol Genomics 2: 49–51, 2000.—The value of the zebrafish (Danio rerio) as a model for human disease has been substantiated by a number of recently published papers. Several zebrafish mutants with "human" diseases have been found, spanning a variety of human pathologies. These successful studies utilizing the zebrafish have been made possible by the development of key reagents such as YAC, PAC, and BAC libraries, as well as radiation hybrid panels. With the further establishment of new tools and access to the newly generated resources, the zebrafish is poised to serve as a novel model for human disease.

positional cloning; human disease models; mutagenesis screens; hematopoiesis

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