Supplemental Figures and Tables

5 figures, 6 tables, and detailed methodology of computational models in PODF format.

Files in this Data Supplement:

• Figure S1 - IV-Infusion of sVEGFR1: Biotransport Dependence I. Varying vascular permeability transport of sVEGFR1∙VEGF complex.
• Figure S2 - IV-Infusion of sVEGFR1: Biotransport Dependence II. Varying vascular permeability transport of free sVEGFR1 and sVEGFR1∙VEGF complex. Red arrow indicates net attenuation in steady-state plasma concentrations of free VEGF.
• Figure S3 - IV-Infusion of sVEGFR1: Biotransport Dependence III. Complete blockade of lymphatic drainage of sVEGFR1∙VEGF complex; and varying vascular permeability transport of sVEGFR1∙VEGF complex. Red arrow indicates net attenuation in steady-state plasma concentrations of free VEGF.
• Figure S4 - IV-Infusion of sVEGFR1: Biotransport Dependence IV. Complete blockade of lymphatic drainage of sVEGFR1∙VEGF complex; and varying vascular permeability transport of free sVEGFR1 and sVEGFR1∙VEGF complex. Red arrow indicates net attenuation in steady-state plasma concentrations of free VEGF.
• Figure S5 - Healthy Patient: Complete Molecular Distrribution Analysis for Varying Isoform Ratio in VEGF Secretion Rate (qV121: qV165) from the Calf. (A) Free VEGF and free sVEGFR1 distributions. (B) Total sVEGFR1 distribution. (C) Total VEGF121 distribution. (D) Total VEGF165 distribution. (E) Extracellular matrix binding site occupancies. (F) Endothelial basement membrane binding site occupancies. (G) Parenchymal basement membrane binding site occupancies. (H) VEGFR1 occupancies. (I)VEGFR2 occupancies. (J) NRP1 occupancies. (K) VEGF-bound VEGFR complexes.
• Detailed Methodology - the Computational Model.