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Contents: Volume 14, Release 2; 7 July 2003
[Index by Author]
[Cover Caption]
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Gene expression changes in major lung proteins (CC10 and surfactant protein C), a key enzyme in the eukaryotic cell's response to oxidative stress (glutathione S-transferase), and cell cycle check point proteins (cyclin G and cyclin B1) resulting from hyperoxic lung damage. Cyclosporin A reversed the cyclin B1-mediated changes in gene expression. Background shows distal lung immunohistochemical detection of cyclin B1 after hyperoxia/cyclosporin A. Image by G. Doerman, E. Matthew, and J. Dedman. See related article by Matthew E, Kutcher L, and Dedman J. Physiol Genomics 14: 129-138, 2003. First published May 27, 2003; 10.1152/physiolgenomics.00130.2002.
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