Physiol. Genomics -- Table of Contents (February 13 2004, 16 [3])

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Editorial:

Allen W. Cowley, Jr.: The elusive field of systems biology
Physiol. Genomics 16: 285-286, 2004; doi:10.1152/physiolgenomics.00007.2004 [Full Text] [PDF]

Invited Reviews:

Maria Teresa Discenza and Jerry Pelletier: Insights into the physiological role of WT1 from studies of genetically modified mice
Physiol. Genomics 16: 287-300, 2004; doi:10.1152/physiolgenomics.00164.2003 [Abstract] [Full Text] [PDF]

Research Articles:

Alexandra Vanessa Finsen, Per Reidar Woldbaek, Jian Li, Jiaping Wu, Torstein Lyberg, Theis Tønnessen, and Geir Christensen: Increased syndecan expression following myocardial infarction indicates a role in cardiac remodeling
Physiol. Genomics 16: 301-308, 2004. First published November 18, 2003; doi:10.1152/physiolgenomics.00144.2002 [Abstract] [Full Text] [PDF]

Christine Dos Santos, Daniele Fallin, Catherine Le Stunff, Sophie LeFur, and Pierre Bougnères: INS VNTR is a QTL for the insulin response to oral glucose in obese children
Physiol. Genomics 16: 309-313, 2004. First published December 2, 2003; doi:10.1152/physiolgenomics.00024.2003 [Abstract] [Full Text] [PDF]

Ping Liang, Craig A. Jones, Brent W. Bisgrove, Lei Song, Sean T. Glenn, H. Joseph Yost, and Kenneth W. Gross: Genomic characterization and expression analysis of the first nonmammalian renin genes from zebrafish and pufferfish
Physiol. Genomics 16: 314-322, 2004. First published November 25, 2003; doi:10.1152/physiolgenomics.00012.2003 [Abstract] [Full Text] [PDF] [Supplemental Materials]

John H. Eisenach, Antonio M. McGuire, Rachel M. Schwingler, Stephen T. Turner, and Michael J. Joyner: The Arg16/Gly ß₂-adrenergic receptor polymorphism is associated with altered cardiovascular responses to isometric exercise
Physiol. Genomics 16: 323-328, 2004. First published December 9, 2003; doi:10.1152/physiolgenomics.00152.2003 [Abstract] [Full Text] [PDF]

Nelson Ruiz-Opazo and John Tonkiss: X-linked loci influence spatial navigation performance in Dahl rats
Physiol. Genomics 16: 329-333, 2004. First published December 9, 2003; doi:10.1152/physiolgenomics.00162.2003 [Abstract] [Full Text] [PDF]

J. L. Griffin, C. K. Cemal, and M. A. Pook: Defining a metabolic phenotype in the brain of a transgenic mouse model of spinocerebellar ataxia 3
Physiol. Genomics 16: 334-340, 2004. First published December 16, 2003; doi:10.1152/physiolgenomics.00149.2003 [Abstract] [Full Text] [PDF]

Robert J. Feezor, Heather N. Paddock, Henry V. Baker, Juan C. Varela, Joyce Barreda, Lyle L. Moldawer, Gregory S. Schultz, and David W. Mozingo: Temporal patterns of gene expression in murine cutaneous burn wound healing
Physiol. Genomics 16: 341-348, 2004; doi:10.1152/physiolgenomics.00101.2003 [Abstract] [Full Text] [PDF]

Toolbox:

Oleg Tarnavski, Julie R. McMullen, Martina Schinke, Qing Nie, Sekwon Kong, and Seigo Izumo: Mouse cardiac surgery: comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies
Physiol. Genomics 16: 349-360, 2004. First published December 16, 2003; doi:10.1152/physiolgenomics.00041.2003 [Abstract] [Full Text] [PDF]

Nancy Mah, Anders Thelin, Tim Lu, Susanna Nikolaus, Tanja Kühbacher, Yesim Gurbuz, Holger Eickhoff, Günther Klöppel, Hans Lehrach, Björn Mellgård, Christine M. Costello, and Stefan Schreiber: A comparison of oligonucleotide and cDNA-based microarray systems
Physiol. Genomics 16: 361-370, 2004. First published November 25, 2003; doi:10.1152/physiolgenomics.00080.2003 [Abstract] [Full Text] [PDF] [Supplemental table and figures]

Cover Caption:

Cover

Cover: Gene discovery and the characterization of tissues based on microarray gene expression database mining and profiling. Top: portion of a Pearson correlation hierarchical tree clustering of genes and tissues using 269 "olfactorome" genes, so called based on their high relative expression in olfactory mucosa samples versus 81 different mouse tissue samples. Tissues and genes that share similar expression profiles are grouped on the same parent of their hierarchical tree branch. Each row represents a gene and each column a mouse tissue sample. Red indicates high expression, blue indicates low expression. Bottom: in vivo localization of highly expressed genes in the olfactory mucosa using in situ hybridization and immunohistochemical localization. In situ hybridization (left) demonstrates olfactory mucosa localization of Plunc mRNA, the gene with the highest relative expression in olfactory mucosa compared to all other tissues in the expression database (signal appears as punctate bright white foci). Enzyme activity measurements and immunohistochemical localization (right) confirmed high expression of Spgl1 (encoding sphingosine phosphate lyase), which had not been localized in olfactory mucosa previously. Strong staining is present within mature olfactory sensory neurons (red peri-nuclear reaction product). For further discussion, see article by Genter MB, Van Veldhoven PP, Jegga AG, Sakthivel B, Kong S, Stanley K, Witte DP, Ebert CL, and Aronow BJ. Microarray-based discovery of highly expressed olfactory mucosal genes: potential roles in the various functions of the olfactory system. Physiol Genomics 16: 67-81, 2003. First published October 21, 2003; 10.1152/physiolgenomics.00117.2003.