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Cover Caption:
Cover: Phylogenetic tree and structures of the main retinoblastoma-related (RBR) subfamilies. Mutations in the parkin gene cause autosomal-recessive juvenile parkinsonism. Parkin encodes a ubiquitin-protein ligase characterized by having the RBR domain, composed of two RING fingers plus an IBR/DRIL domain. The tree was generated using the "neighbor-joining" and "maximum parsimony" methods implemented in MEGA 2.1. For additional details, see Marín I, Lucas JI, Gradilla AC, and Ferrús A. Parkin and relatives: the RBR family of ubiquitin ligases. Physiol. Genomics 17: 253-263, 2004; 10.1152/physiolgenomics.00226.2003.
Copyright © 2004 by the American Physiological Society.