Physiol. Genomics -- Table of Contents (November 17 2005, 23 [3])

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Research Articles:

Victoria L. M. Herrera, Lorenz R. B. Ponce, Pia D. Bagamasbad, Benjamin D. VanPelt, Tamara Didishvili, and Nelson Ruiz-Opazo: Embryonic lethality in Dear gene-deficient mice: new player in angiogenesis
Physiol. Genomics 23: 257-268, 2005; doi:10.1152/physiolgenomics.00144.2005 [Abstract] [Full Text] [PDF]

Francesca Puppo, Marco Musso, Doroti Pirulli, Paola Griseri, Tiziana Bachetti, Sergio Crovella, Giovanna Patrone, Isabella Ceccherini, and Roberto Ravazzolo: Comparative genomic sequence analysis coupled to chromatin immunoprecipitation: a screening procedure applied to search for regulatory elements at the RET locus
Physiol. Genomics 23: 269-274, 2005. First published September 6, 2005; doi:10.1152/physiolgenomics.00036.2005 [Abstract] [Full Text] [PDF]

P. D. Bowman, J. L. Sondeen, B. Zhao, V. G. Coppes, J. J. Nelson, M. A. Dubick, and G. M. Vaughan: A temporal study of gene expression in rat lung following fixed-volume hemorrhage
Physiol. Genomics 23: 275-286, 2005. First published September 13, 2005; doi:10.1152/physiolgenomics.00075.2005 [Abstract] [Full Text] [PDF] [Online Supplement]

Derek Zieker, Elvira Fehrenbach, Janko Dietzsch, Judith Fliegner, Marc Waidmann, Kay Nieselt, Peter Gebicke-Haerter, Rainer Spanagel, Perikles Simon, Andreas Michael Niess, and Hinnak Northoff: cDNA microarray analysis reveals novel candidate genes expressed in human peripheral blood following exhaustive exercise
Physiol. Genomics 23: 287-294, 2005. First published August 23, 2005; doi:10.1152/physiolgenomics.00096.2005 [Abstract] [Full Text] [PDF]

Jennifer E. Foreman, David A. Blizard, Glenn Gerhard, Holly A. Mack, Dean H. Lang, Kathryn L. Van Nimwegen, George P. Vogler, Joseph T. Stout, Zakariya K. Shihabi, James W. Griffith, Joan M. Lakoski, Gerald E. McClearn, and David J. Vandenbergh: Serum alkaline phosphatase activity is regulated by a chromosomal region containing the alkaline phosphatase 2 gene (Akp2) in C57BL/6J and DBA/2J mice
Physiol. Genomics 23: 295-303, 2005. First published September 13, 2005; doi:10.1152/physiolgenomics.00062.2005 [Abstract] [Full Text] [PDF]

Bin Zhao, Ramesh Natarajan, and Shobha Ghosh: Human liver cholesteryl ester hydrolase: cloning, molecular characterization, and role in cellular cholesterol homeostasis
Physiol. Genomics 23: 304-310, 2005. First published August 30, 2005; doi:10.1152/physiolgenomics.00187.2005 [Abstract] [Full Text] [PDF]

Sherry O. Kasper, Christy S. Carter, Carlos M. Ferrario, Detlev Ganten, Leon F. Ferder, William E. Sonntag, Patricia E. Gallagher, and Debra I. Diz: Growth, metabolism, and blood pressure disturbances during aging in transgenic rats with altered brain renin-angiotensin systems
Physiol. Genomics 23: 311-317, 2005. First published August 30, 2005; doi:10.1152/physiolgenomics.00163.2005 [Abstract] [Full Text] [PDF]

Bina Joe, Noah E. Letwin, Michael R. Garrett, Seema Dhindaw, Bryan Frank, Razvan Sultana, Kathleen Verratti, John P. Rapp, and Norman H. Lee: Transcriptional profiling with a blood pressure QTL interval-specific oligonucleotide array
Physiol. Genomics 23: 318-326, 2005. First published October 4, 2005; doi:10.1152/physiolgenomics.00164.2004 [Abstract] [Full Text] [PDF] [Supplemental Methods]

Joshua C. Kwekel, Lyle D. Burgoon, Jeremy W. Burt, Jack R. Harkema, and Timothy R. Zacharewski: A cross-species analysis of the rodent uterotrophic program: elucidation of conserved responses and targets of estrogen signaling
Physiol. Genomics 23: 327-342, 2005. First published September 20, 2005; doi:10.1152/physiolgenomics.00175.2005 [Abstract] [Full Text] [PDF] [Supplemental Tables]

Joseph M. Dhahbi, Patricia L. Mote, Gregory M. Fahy, and Stephen R. Spindler: Identification of potential caloric restriction mimetics by microarray profiling
Physiol. Genomics 23: 343-350, 2005. First published September 27, 2005; doi:10.1152/physiolgenomics.00069.2005 [Abstract] [Full Text] [PDF]

Cover Caption:

Cover Cover: Overview of physiological genomics in the rat and the various translational technologies available to relate rat research to human systems. Left: the traditional positional cloning process wherein 2 rats, 1 possessing the phenotype of interest and the other an unaffected control strain, are crossed. The progeny are genotyped and phenotyped, leading to the definition of quantitative trait loci linking the phenotype to specific regions of the genome. The regions are then examined for potential candidate genes, and comparative genomics is used to integrate evidence from other organisms or to translate results to the human genome. Translation of information to the human system is also becoming possible using informatic tools such as ontologies. Various ontologies are shown connecting elements of the experimental paradigm to related human data. For details, see Twigger SN, Pasko D, Nie J, Shimoyama M, Bromberg S, Campbell D, Chen J, dela Cruz N, Fan C, Foote C, Harris G, Hickmann B, Ji Y, Jin W, Li D, Mathis J, Nenasheva N, Nigam R, Petri V, Reilly D, Ruotti V, Schauberger E, Seiler K, Slyper R, Smith J, Wang W, Wu W, Zhao L, Zuniga-Meyer A, Tonellato PJ, Kwitek AE, and Jacob HJ. Tools and strategies for physiological genomics: the Rat Genome Database. Physiol. Genomics 23: 246-256, 2005 First published August 16, 2005; doi: 10.1152/physiolgenomics.00040.2005.