Physiol. Genomics -- Table of Contents (September 3 2006, 27 [1])

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Invited Reviews:

Bina Joe: Quest for arthritis-causative genetic factors in the rat
Physiol. Genomics 27: 1-11, 2006. First published June 27, 2006; doi:10.1152/physiolgenomics.00034.2005 [Abstract] [Full Text] [PDF]

Research Articles:

Carlos Díez-Freire, Jorge Vázquez, María F. Correa de Adjounian, Merari F. R. Ferrari, Lihui Yuan, Xeve Silver, Raquel Torres, and Mohan K. Raizada: ACE2 gene transfer attenuates hypertension-linked pathophysiological changes in the SHR
Physiol. Genomics 27: 12-19, 2006. First published June 20, 2006; doi:10.1152/physiolgenomics.00312.2005 [Abstract] [Full Text] [PDF]

Alfred C. Aplin, Maurizio Gelati, Eric Fogel, Edvige Carnevale, and Roberto F. Nicosia: Angiopoietin-1 and vascular endothelial growth factor induce expression of inflammatory cytokines before angiogenesis
Physiol. Genomics 27: 20-28, 2006; doi:10.1152/physiolgenomics.00048.2006 [Abstract] [Full Text] [PDF] [Supplemental Table]

Juan J. Loor, Heather M. Dann, Nicole A. Janovick Guretzky, Robin E. Everts, Rosane Oliveira, Cheryl A. Green, Noah B. Litherland, Sandra L. Rodriguez-Zas, Harris A. Lewin, and James K. Drackley: Plane of nutrition prepartum alters hepatic gene expression and function in dairy cows as assessed by longitudinal transcript and metabolic profiling
Physiol. Genomics 27: 29-41, 2006. First published June 6, 2006; doi:10.1152/physiolgenomics.00036.2006 [Abstract] [Full Text] [PDF] [Supplemental Materials]

Robert W. Li, Matthew J. Meyer, Curtis. P. Van Tassell, Tad S. Sonstegard, Erin E. Connor, Michael E. Van Amburgh, Yves R. Boisclair, and Anthony V. Capuco: Identification of estrogen-responsive genes in the parenchyma and fat pad of the bovine mammary gland by microarray analysis
Physiol. Genomics 27: 42-53, 2006. First published June 20, 2006; doi:10.1152/physiolgenomics.00032.2006 [Abstract] [Full Text] [PDF] [Supplementary Material]

Aaron Avivi, Leonid Brodsky, Eviatar Nevo, and Mark R. Band: Differential expression profiling of the blind subterranean mole rat Spalax ehrenbergi superspecies: bioprospecting for hypoxia tolerance
Physiol. Genomics 27: 54-64, 2006. First published June 20, 2006; doi:10.1152/physiolgenomics.00001.2006 [Abstract] [Full Text] [PDF] [Supplementary Data]

Nada Radoja, Alix Gazel, Tomohiro Banno, Shoichiro Yano, and Miroslav Blumenberg: Transcriptional profiling of epidermal differentiation
Physiol. Genomics 27: 65-78, 2006. First published July 5, 2006; doi:10.1152/physiolgenomics.00031.2006 [Abstract] [Full Text] [PDF] [Supplementary Table]

Madhusudhan R. Papasani, Barrie D. Robison, Ronald W. Hardy, and Rodney A. Hill: Early developmental expression of two insulins in zebrafish (Danio rerio)
Physiol. Genomics 27: 79-85, 2006. First published July 18, 2006; doi:10.1152/physiolgenomics.00012.2006 [Abstract] [Full Text] [PDF] [Supplement Figures]

Maria Mirotsou, Victor J. Dzau, Richard E. Pratt, and Ellen O. Weinberg: Physiological genomics of cardiac disease: quantitative relationships between gene expression and left ventricular hypertrophy
Physiol. Genomics 27: 86-94, 2006. First published July 11, 2006; doi:10.1152/physiolgenomics.00028.2006 [Abstract] [Full Text] [PDF] [Supplemental Table]

Ondrej Seda, Lucie Sedová, Frantisek Liska, Drahomíra Krenová, Vratislav Prejzek, Ludmila Kazdová, Johanne Tremblay, Pavel Hamet, and Vladimír Kren: Novel double-congenic strain reveals effects of spontaneously hypertensive rat chromosome 2 on specific lipoprotein subfractions and adiposity
Physiol. Genomics 27: 95-102, 2006. First published July 5, 2006; doi:10.1152/physiolgenomics.00039.2006 [Abstract] [Full Text] [PDF] [Supplemental Figure and Table]

Cover Caption:

Cover

Cover: Overview of interactions among gene expression profiles in liver and physiological events in visceral adipose, skeletal muscle, and liver tissue during the periparturient period in dairy cows fed ad libitum or provided restricted feeding of moderate-energy diets. Overfeeding of energy prepartum induces chronic hyperinsulinemia, which plays a central role in physiological and molecular adaptations occurring in visceral adipose and liver. These cows have lower capacity to completely oxidize nonesterified fatty acids (NEFA) in liver (↓ ADIPOR2,↓ ACADVL, ↓ ACAA1, ↓ CPT1A mRNA) but have higher capacity to store triacylglycerol postpartum (↑ AGPAT1, ↑ DGAT1, ↑ MTP mRNA). Restricted energy intake prepartum allows for upregulation of fatty acid oxidation, gluconeogenesis, and cholesterogenesis and prevents excessive oxidative stress and DNA damage. Therefore, controlled energy intake prepartum would be advantageous to the cow as the liver “adjusts” its metabolic activity to the onset of parturition. Uncontrolled triacylglycerol accumulation in liver and oxidative stress increases the risk of periparturient health disorders by predisposing the cow to fatty liver and ketosis, which could increase steatotic hepatocyte through upregulation of TP53 mRNA. For details, see Loor JJ, Dann HM, Janovick Guretzky NA, Everts RE, Oliveira R, Green CA, Litherland NB, Rodriguez-Zas SL, Lewin HA, Drackley JK. Plane of nutrition prepartum alters hepatic gene expression and function in dairy cows as assessed by longitudinal transcript and metabolic profiling. Physiol Genomics 27: 29-41, 2006; doi:10.1152/physiolgenomics.00036.2006.