Physiol. Genomics -- Table of Contents (September 2009, 39 [1])

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Call For Papers: Comparative Genomics:

D. Claire Wathes, Zhangrui Cheng, Waliul Chowdhury, Mark A. Fenwick, Richard Fitzpatrick, Dermot G. Morris, Joe Patton, and John J. Murphy: Negative energy balance alters global gene expression and immune responses in the uterus of postpartum dairy cows
Physiol. Genomics 39: 1-13, 2009. First published June 30, 2009; doi:10.1152/physiolgenomics.00064.2009 [Abstract] [Full Text] [PDF] [Supplemental Tables]

Nadéra Mansouri-Attia, Julie Aubert, Pierrette Reinaud, Corinne Giraud-Delville, Géraldine Taghouti, Laurent Galio, Robin E. Everts, Séverine Degrelle, Christophe Richard, Isabelle Hue, Xiangzhong Yang, X. Cindy Tian, Harris A. Lewin, Jean-Paul Renard, and Olivier Sandra: Gene expression profiles of bovine caruncular and intercaruncular endometrium at implantation
Physiol. Genomics 39: 14-27, 2009. First published July 21, 2009; doi:10.1152/physiolgenomics.90404.2008 [Abstract] [Full Text] [PDF] [Supplemental Figures and Tables]

Research Articles:

D. G. Morris, S. M. Waters, S. D. McCarthy, J. Patton, B. Earley, R. Fitzpatrick, J. J. Murphy, M. G. Diskin, D. A. Kenny, A. Brass, and D. C. Wathes: Pleiotropic effects of negative energy balance in the postpartum dairy cow on splenic gene expression: repercussions for innate and adaptive immunity
Physiol. Genomics 39: 28-37, 2009. First published June 30, 2009; doi:10.1152/physiolgenomics.90394.2008 [Abstract] [Full Text] [PDF] [Supplemental Figures and Tables]

Marcelo A. Nobrega, Leah C. Solberg Woods, Stewart Fleming, and Howard J. Jacob: Distinct genetic regulation of progression of diabetes and renal disease in the Goto-Kakizaki rat
Physiol. Genomics 39: 38-46, 2009. First published July 7, 2009; doi:10.1152/physiolgenomics.90389.2008 [Abstract] [Full Text] [PDF] [Supplemental Figures]

He S. Yang, Martha H. Vitaterna, Aaron D. Laposky, Kazuhiro Shimomura, and Fred W. Turek: Genetic analysis of daily physical activity using a mouse chromosome substitution strain
Physiol. Genomics 39: 47-55, 2009. First published June 30, 2009; doi:10.1152/physiolgenomics.00066.2009 [Abstract] [Full Text] [PDF]

Maja Barbalic, Gary L. Schwartz, Arlene B. Chapman, Stephen T. Turner, and Eric Boerwinkle: Kininogen gene (KNG) variation has a consistent effect on aldosterone response to antihypertensive drug therapy: the GERA study
Physiol. Genomics 39: 56-60, 2009. First published July 7, 2009; doi:10.1152/physiolgenomics.00061.2009 [Abstract] [Full Text] [PDF]

John Zagorski, Maria Obraztsova, Michael A. Gellar, Jeffrey A. Kline, and John A. Watts: Transcriptional changes in right ventricular tissues are enriched in the outflow tract compared with the apex during chronic pulmonary embolism in rats
Physiol. Genomics 39: 61-71, 2009. First published July 14, 2009; doi:10.1152/physiolgenomics.00076.2009 [Abstract] [Full Text] [PDF] [Supplemental Figures and Tables]

B. Kutlu, A. G. Kayali, S. Jung, G. Parnaud, D. Baxter, G. Glusman, N. Goodman, L. A. Behie, A. Hayek, and L. Hood: Meta-analysis of gene expression in human pancreatic islets after in vitro expansion
Physiol. Genomics 39: 72-81, 2009. First published July 21, 2009; doi:10.1152/physiolgenomics.00063.2009 [Abstract] [Full Text] [PDF] [Supplemental Data]

Cover Caption:

Cover

Cover: Experimental pulmonary embolism (PE) causes right ventricular heart strain and acute inflammation followed by tissue remodeling in rats. The right ventricular outflow tract of the heart appears translucent 6 wk after PE compared with the apex region (top inset). Histological changes, shown with Masson's trichrome stain, indicate a transition between heart muscle (red myocytes in cross section) and the remodeling tissue in the PE outflow region, where myofibroblast and monocyte cells are present (dark nuclei), fibrotic collagen deposition (blue) occurs, and few myocytes (red) remain (top). In contrast, the outflow tract and apex of the normal hearts are red throughout, and the heart (bottom inset) and histology show normal myocyte structure in cross section (red) with normal collagen (blue) distribution (bottom). DNA microarray analysis demonstrated major transcriptional changes that were focused in the outflow region compared with the apex of the PE hearts or the same regions of the normal heart (right; red and green indicate up- and downregulation of gene expression in normal apex, normal outflow, PE apex, and PE outflow; top 20 red genes, bottom 20 green genes, and 15 genes at the red-green boundary are shown). Consistent with myocyte depletion, genes for cellular respiration and energy metabolism were decreased, and genes for leukocyte cell adhesion, extracellular matrix proteins, and signal pathways for wound healing were increased in the PE outflow tract. For details, see Zagorski J, Obraztsova M, Gellar MA, Kline JA, and Watts JA. Transcriptional changes in right ventricular tissues are enriched in the outflow tract compared with the apex during chronic pulmonary embolism in rats. Physiol Genomics 39: 61–71, 2009.